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Epidermal Langerhans Cells - Gerold Schuler - inbunden

De flesta insjuknar före tio års ålder, men även vuxna kan drabbas. Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. They specialize in antigen presentation and belong to the skin immune system (SIS). 2021-01-25 · A Langerhans cell is a specific kind of white blood cell. Found largely in the epidermis, the outer layer of the skin, as well as in lymph nodes, Langerhans cells are an important element of the immune system. They are classified as dendritic cells because they grow projections called dendrites as they develop.

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Research output: Contribution to journal › Article. New views on epidermis and its Langerhans cells in the normal state and in contact dermatitis Lund university logotype. Box 117, 221 00 Lund, Sweden Langerhans´ cellhistiocytos (LCH) benämndes tidigare histiocytosis X, »a reactive, non-neoplastic proliferation of the Langerhans cells« [19]. Pris: 5359 kr.

Expert Opin Pharmacother 2005; 6: 2435-41. PubMed; Writing  Symposium The Langerhans' Cell and Contact Dermatitis, Gimo, 1-2 October, 1977 by Symposium "The Langerhans' Cell and Contact Dermatitis"( Book ) infiltrate in the Langerhans Cell Histiocytosis lesion, and discuss the results of examine the functions of regulatory T cells in thrombus resolution in a mouse  DC beskrevs först av Paul Langerhans (Langerhans celler) i slutet av själv molekyler resulterar i T-cells unresponsiveness och apoptos 5. Langerhans-cell granulomatos kan involvera ett enda organ eller kan vara en the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS  av B FADEEL · Citerat av 2 — An hypothesis.

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Langerhans cells (LC) are a unique population of tissue-resident macrophages that form a network of cells across the epidermis of the skin, but which have the ability to migrate from the epidermis to draining lymph nodes. Their location at the skin barrier suggests a key role as immune sentinels.

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This book is about the phenotypic and functional features of epidermal Langerhans cells in experimental models and in clinical medicine. Langerhans cells  Mediated exodus of L-dopa from human epidermal Langerhans cells.

Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. They specialize in antigen presentation and belong to the skin immune system (SIS). 2021-01-25 · A Langerhans cell is a specific kind of white blood cell. Found largely in the epidermis, the outer layer of the skin, as well as in lymph nodes, Langerhans cells are an important element of the immune system. They are classified as dendritic cells because they grow projections called dendrites as they develop. Langerhans cell histiocytosis is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes.
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They can be found in the skin, lungs, stomach, bone, eyes and intestines. In LCH, dendritic cells build up, forming tumors Langerhans Cell Histiocytosis (LCH) is a collection of rare disorders of the mononuclear phagocytes and dendritic cells. Other disorders similar to LCH include Histiocytoses Rosai-Dorfman, juvenile xanthogranuloma, and Erdheim-Chester disease but they do not share the exact phenotypic signature of LCH. Histiocytic sarcoma (G), like Langerhans cell sarcoma (H), demonstrates large pleomorphic atypical cells; however, the cells of histiocytic sarcoma are generally larger than those of Langerhans cell sarcoma and show less nuclear complexity (hematoxylin-eosin, original magnification X400). Our assumptions on the identity and functions of Langerhans cells (LCs) of the epidermis have undergone considerable changes. Once thought to be prototypic representatives of the dendritic cell (DC) lineage, they are now considered to be a specialized subset of tissue-resident macrophages.

Cell nuclei stain blue. Original magnification ×250.
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Langerhans cell-histiocytos Barncancerfonden

Although these cells were primarily thought to play a defensive role in the skin, evidence now indicates a diverse range of LC‐mediated effects including the relay of viral antigens in herpes simplex infection, recruitment of eosinophils in atopic dermatitis and promotion of a Th17 response in Candida infection.